Defensin, beta 1

Defensin, beta 1

PDB rendering based on 1e4s.

Available structures
PDB	1E4S, 1IJU, 1IJV, 1KJ5, 2NLB, 2NLC, 2NLD, 2NLE, 2NLF, 2NLG, 2NLH, 2NLP, 2NLQ, 2NLS, 2PLZ

Identifiers

DEFB1; BD1; DEFB-1; DEFB101; HBD1; MGC51822

External IDs

OMIM: 602056 HomoloGene: 88476 GeneCards: DEFB1 Gene

Gene Ontology
Cellular component	• extracellular region
Biological process	• chemotaxis • immune response • G-protein coupled receptor protein signaling pathway • response to bacterium • response to bacterium • defense response to bacterium • innate immune response • innate immune response
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

ENSG00000164825

n/a

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)

Chr 8:
6.73 – 6.74 Mb

n/a

PubMed search

n/a

Beta-defensin 1 is a protein that in humans is encoded by the DEFB1 gene.^[1]^[2]

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member defensin, alpha 1, and has been implicated in the pathogenesis of cystic fibrosis.^[2]

References

^ Bensch KW, Raida M, Magert HJ, Schulz-Knappe P, Forssmann WG (Sep 1995). "hBD-1: a novel beta-defensin from human plasma". FEBS Lett 368 (2): 331–5. doi:10.1016/0014-5793(95)00687-5. PMID 7628632.
^ ^a ^b "Entrez Gene: DEFB1 defensin, beta 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1672.

Further reading

Ganz T, Lehrer RI (1995). "Defensins.". Pharmacol. Ther. 66 (2): 191–205. doi:10.1016/0163-7258(94)00076-F. PMID 7667395.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Goldman MJ, Anderson GM, Stolzenberg ED, et al. (1997). "Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis.". Cell 88 (4): 553–60. doi:10.1016/S0092-8674(00)81895-4. PMID 9038346.
McCray PB, Bentley L (1997). "Human airway epithelia express a beta-defensin.". Am. J. Respir. Cell Mol. Biol. 16 (3): 343–9. PMID 9070620.
Liu L, Zhao C, Heng HH, Ganz T (1997). "The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry.". Genomics 43 (3): 316–20. doi:10.1006/geno.1997.4801. PMID 9268634.
Valore EV, Park CH, Quayle AJ, et al. (1998). "Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.". J. Clin. Invest. 101 (8): 1633–42. doi:10.1172/JCI1861. PMC 508744. PMID 9541493. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=508744.
Schnapp D, Reid CJ, Harris A (1999). "Localization of expression of human beta defensin-1 in the pancreas and kidney.". J. Pathol. 186 (1): 99–103. doi:10.1002/(SICI)1096-9896(199809)186:1<99::AID-PATH133>3.0.CO;2-#. PMID 9875146.
Hiratsuka T, Nakazato M, Ashitani J, Matsukura S (1999). "[A study of human beta-defensin-1 and human beta-defensin-2 in airway mucosal defense]". Kansenshogaku Zasshi 73 (2): 156–62. PMID 10213993.
Gropp R, Frye M, Wagner TO, Bargon J (1999). "Epithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy.". Hum. Gene Ther. 10 (6): 957–64. doi:10.1089/10430349950018355. PMID 10223729.
Mathews M, Jia HP, Guthmiller JM, et al. (1999). "Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands.". Infect. Immun. 67 (6): 2740–5. PMC 96577. PMID 10338476. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=96577.
Bøe R, Silvola J, Yang J, et al. (1999). "Human beta-defensin-1 mRNA is transcribed in tympanic membrane and adjacent auditory canal epithelium.". Infect. Immun. 67 (9): 4843–6. PMC 96817. PMID 10456939. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=96817.
Yang D, Chertov O, Bykovskaia SN, et al. (1999). "Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.". Science 286 (5439): 525–8. doi:10.1126/science.286.5439.525. PMID 10521347.
Tunzi CR, Harper PA, Bar-Oz B, et al. (2000). "Beta-defensin expression in human mammary gland epithelia.". Pediatr. Res. 48 (1): 30–5. doi:10.1203/00006450-200007000-00008. PMID 10879797.
Sahasrabudhe KS, Kimball JR, Morton TH, et al. (2000). "Expression of the antimicrobial peptide, human beta-defensin 1, in duct cells of minor salivary glands and detection in saliva.". J. Dent. Res. 79 (9): 1669–74. doi:10.1177/00220345000790090601. PMID 11023262.
Jia HP, Starner T, Ackermann M, et al. (2001). "Abundant human beta-defensin-1 expression in milk and mammary gland epithelium.". J. Pediatr. 138 (1): 109–12. doi:10.1067/mpd.2001.109375. PMID 11148522.
Ali RS, Falconer A, Ikram M, et al. (2001). "Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin.". J. Invest. Dermatol. 117 (1): 106–11. doi:10.1046/j.0022-202x.2001.01401.x. PMID 11442756.
Carothers DG, Graham SM, Jia HP, et al. (2001). "Production of beta-defensin antimicrobial peptides by maxillary sinus mucosa.". American journal of rhinology 15 (3): 175–9. doi:10.2500/105065801779954238. PMID 11453504.
Hoover DM, Chertov O, Lubkowski J (2001). "The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.". J. Biol. Chem. 276 (42): 39021–6. doi:10.1074/jbc.M103830200. PMID 11486002.

PDB gallery

1e4s: SOLUTION STRUCTURE OF THE HUMAN DEFENSIN HBD-1

1iju: HUMAN BETA-DEFENSIN-1

1ijv: HUMAN BETA-DEFENSIN-1

1kj5: Solution Structure of Human beta-defensin 1

2nlb: Human beta-defensin-1 (Mutant Asn4Ala)

2nlc: Human beta-defensin-1 (mutant Ser8Ala)

2nld: Human beta-defensin-1 (Mutant Gln11Ala)

2nle: Human beta-defensin-1 (Mutant Gln11Ala)

2nlf: Human beta-defensin-1 (Mutant Leu13Glu)

2nlg: Human beta-defensin-1 (Mutant Lys22Glu)

2nlh: Human beta-defensin-1 (Mutant GLN24ALA)

2nlp: Human beta-defensin-1 (Mutant Gln24Glu)

2nlq: Human beta-defensin-1 (Mutant Lys31Ala)

2nls: Human beta-defensin-1 (Mutant Gln24Ala)